Localized Drug Delivery Systems: An Update on Treatment Options for Head and Neck Squamous Cell Carcinomas

Head and neck squamous cell carcinoma (HNSCC) is one of the most common cancers in world, with surgery, radiotherapy, chemotherapy, immunotherapy being primary treatment modalities. The for HNSCC has evolved over time, due to which prognosis improved drastically. Despite varied options, major challenges persist. chemotherapeutic immunotherapeutic drugs are usually administered systemically, could affect patient’s quality life associated side effects. Moreover, systemic administration salivary stimulating agents radiation-induced xerostomia toxicities. Localized drug delivery systems (LDDS) gaining importance, as they have potential provide non-invasive, patient-friendly alternatives cancer therapy reduced dose-limiting LDDSs involve directly delivering a tissue or organ affected by disease. Some localized routes include transdermal transmucosal system (DDSs). This review will attempt explore different options using radiotherapy-induced damage their better experience patients, well obstacles that need be addressed render them successful.